CrossTalk opposing view: mucosal acidification does not drive early progressive lung disease in cystic fibrosis
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چکیده
منابع مشابه
CrossTalk opposing view: 5-HT is not necessary for peristalsis.
Large quantities of 5-hydroxytryptamine (5-HT) are synthesized in the gut, in enterochromaffin (EC) cells of the mucosa (via tryptophan hydroxylase-1) and in a small proportion in enteric neurons (via tryptophan hydroxylase-2). It has been well established that 5-HT can be released from the mucosa by mechanical stimulation, including contractile activity of the gut and compression of the gut wa...
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A 32-year-old man was admitted in the Emergency Department with acute dyspnea secondary to spontaneous pneumothorax. He had history of spontaneous pneumothorax 2 years ago.He was active cigarette smoker (10 pack/year). The family history was unremarkable for lung diseases. Additionally, he had no systemic complaints.The lung HRCT revealed multiple bizarre-shaped cysts distributed in both lungs ...
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Sooky Lum, Per Gustafsson, Henrik Ljungberg, Georg Hülskamp, Andrew Bush, Siobhán B Carr, Rosemary Castle, Ah-fong Hoo, John Price, Sarath Ranganathan, John Stroobant, Angie Wade, Colin Wallis, Hilary Wyatt, Janet Stocks on behalf of the London Cystic Fibrosis Collaboration . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
متن کاملInnate immunity in cystic fibrosis lung disease.
Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients. The pulmonary immune response in CF is characterized by an early and non-resolving activation of the innate immune system, which is dysregulated at several levels. Here we provide a comprehensive overview of innate immunity in CF lung disease, involving (i) epithelial dysfunction, (ii) pathogen sensing...
متن کاملNutrition and lung disease in cystic fibrosis.
Among patients who have cystic fibrosis (CF), lung disease is a significant contributor to morbidity. From a clinical perspective, the link between malnutrition and lung dysfunction in CF is well established; however, the causal relationship remains unclear. Nutritional intervention for CF patients is predicated on the hypothesis that improved nutritional status improves pulmonary function. Whi...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2018
ISSN: 0022-3751
DOI: 10.1113/jp275426